Open AccessThe Emerging Role of Circ-SHPRH in Cancer
Author(s) -
X. Ju,
Yan Tang,
Rongfeng Qu,
Shuhong Hao
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s317403
Subject(s) - retinoblastoma , cancer , cancer research , biomarker , microrna , medicine , suppressor , colorectal cancer , adenocarcinoma , hepatocellular carcinoma , downregulation and upregulation , tumor suppressor gene , oncology , gene , biology , carcinogenesis , biochemistry
Circ-SHPRH is a circular RNA that can regulate the expression of target genes by sponging microRNAs (miRNAs) or translating tumor suppressor proteins. Recent studies have suggested that circ-SHPRH may play a role in the development of tumors and cancers. Hence, this paper aimed to review the biological characteristics, molecular mechanisms, and potential clinical significance of circ-SHPRH in a variety of tumors and to evaluate its potential as a new diagnostic and prognostic biomarker.