Open AccessDaam1 Overexpression Promotes Gastric Cancer Progression and Regulates ERK and AKT Signaling Pathways
Author(s) -
Yue Zhang,
Xue Bai,
Yi Zhang,
Yan Li
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s316157
Subject(s) - cancer research , downregulation and upregulation , cell growth , protein kinase b , apoptosis , gene knockdown , pi3k/akt/mtor pathway , mapk/erk pathway , chemistry , biology , signal transduction , microbiology and biotechnology , biochemistry , gene
The dishevelled-associated activator of morphogenesis 1 (DAAM1) has been reported to be closely associated with human cancers. However, its involvement in human gastric cancer (GC) remains largely unexplored. This study aimed to investigate the clinical significance and biological roles of Daam1 in human GC.