Open AccessFSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration
Author(s) -
Yuanjie Liu,
Jie-pin Li,
Ying Zhang,
Mengjun Nie,
Yonghua Zhang,
Shenlin Liu,
Xi Zou
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s314561
Subject(s) - carcinogenesis , gene knockdown , oncogene , smad , cancer research , biology , immunohistochemistry , cancer , downregulation and upregulation , gene silencing , western blot , microbiology and biotechnology , signal transduction , cell cycle , immunology , apoptosis , gene , biochemistry , genetics
Follistatin-related gene 3 ( FSTL3 ), an established oncogene, can modulate target gene expression via members of the transforming growth factor β (TGF-β) superfamily. The present study was conducted to evaluate the expression of FSTL3 in gastric cancer (GC) and to determine its prognostic significance. We also evaluated the possible mechanisms involved in the oncogenic role of FSTL3 in gastric carcinogenesis and development.