Open AccessCelastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation
Author(s) -
Mаhmoud Youns,
Momen Askoura,
Hisham A. Abbas,
Hany G. Attia,
Ahdab N. Khayyat,
Reham M. Goda,
Ahmad J. Almalki,
El-Sayed Khafagy,
Wael A. H. Hegazy
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s313933
Subject(s) - celastrol , pancreatic cancer , cancer research , apoptosis , atf3 , trichostatin a , microarray analysis techniques , cancer , histone deacetylase , biology , medicine , histone , gene expression , gene , promoter , biochemistry
Pancreatic cancer is one of the most serious and lethal human cancers with a snowballing incidence around the world. The natural product celastrol has also been widely documented as a potent anti-inflammatory, anti-angiogenic, and anti-oxidant.