Open AccessA Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway
Author(s) -
Yuchen Xia,
Guihua Wang,
Manli Jiang,
Xueting Liu,
Yan Zhao,
Yinghui Song,
Bimei Jiang,
Demao Zhu,
Ling Hu,
Zhao Zhang,
Ting Cao,
Ji Ming Wang,
Jinyue Hu
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s313507
Subject(s) - glutathione , gene knockdown , programmed cell death , cancer cell , glutathione reductase , cancer research , cell growth , apoptosis , cancer , flow cytometry , microbiology and biotechnology , chemistry , biology , medicine , enzyme , glutathione peroxidase , biochemistry
Glutathione reductase (GSR) provides reduced glutathione (GSH) to maintain redox homeostasis. Inhibition of GSR disrupts this balance, resulting in cell damage, which benefits cancer therapy. However, the effect of GSR inhibition on the tumorigenicity of human cervical cancer is not fully understood.