Open AccessDevelopment and Validation of an Autophagy-Stroma-Based Microenvironment Gene Signature for Risk Stratification in Colorectal Cancer
Author(s) -
Lin Chen,
Kunzi Zhang,
Jian Sun,
Jingtong Tang,
Jianping Zhou
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s312003
Subject(s) - colorectal cancer , gene signature , lasso (programming language) , stromal cell , oncology , proportional hazards model , medicine , autophagy , stroma , cancer , gene , cancer research , bioinformatics , biology , gene expression , computer science , immunohistochemistry , genetics , apoptosis , world wide web
Colorectal cancer is the fourth most common cancer and the second leading cause of cancer-related death in the USA. The aim of this study was to establish a tumor gene signature based on tumor stromal cell and autophagy for predicting the risk of recurrence in patients with colorectal cancer.