Open AccessIdentification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells
Author(s) -
John Lee,
Rongbing Chen,
T. Mohanakumar,
Ross M. Bremner,
Sumeet K. Mittal,
Timothy P. Fleming
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s309388
Subject(s) - afatinib , cancer research , erlotinib , receptor tyrosine kinase , tyrosine kinase , receptor , cabozantinib , erbb3 , medicine , pharmacology , epidermal growth factor receptor , vegf receptors
Esophageal cancer (EC) is an aggressive cancer type that is increasing at a high rate in the US and worldwide. Extensive sequencing of EC specimens has shown that there are no consistent driver mutations that can impact treatment strategies. The goal of this study was to identify activated tyrosine kinase receptors (TKRs) in EC samples as potential targets in the treatment of EC.