Open AccessTargeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review
Author(s) -
Zhitao Chen,
Lele Zhang,
Jiacheng Huang,
Chenchen Ding,
Ting Zhang,
DaLong Wan,
Xue Li
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s305248
Subject(s) - kras , mucoepidermoid carcinoma , medicine , gene , pancreas , pancreatic cancer , exome sequencing , bioinformatics , cancer research , carcinoma , mutation , biology , cancer , genetics
Primary pancreatic mucoepidermoid carcinoma (MEC) is an extremely rare malignant tumor with unclear etiology and pathogenesis. There are only eleven reported cases in English papers published from 1959 to 2020. MEC generally occurs in the salivary gland, but cases in the pancreas have also been reported. Although being considered as a low-grade indolent carcinoma, pancreatic MEC always invades the surrounding lymph node and metastasizes. The prognosis of pancreatic MEC is unsatisfactory. To date, the genetic alterations, mechanistic relationships among mutated genes and signaling pathways of pancreatic MEC are unclear.