Open AccessFunctions and Targets of miR-335 in Cancer
Author(s) -
Lingling Ye,
Fen Wang,
Hao Wu,
Hui Yang,
Yan Yang,
Yajun Ma,
Aili Xue,
Jing Zhu,
Meili Chen,
Jinyan Wang,
Quan An Zhang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s305098
Subject(s) - microrna , oncogene , biomarker , suppressor , cancer research , cancer , metastasis , biology , tumor initiation , bioinformatics , computational biology , medicine , gene , cell cycle , genetics
MicroRNAs (miRNAs) are small non-coding RNAs (18~25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in cancer. The expression level of miR-335 in tissues and cells varies with cancer types, and miR-335 has been proposed as a potential biomarker for the prognosis of cancer. Besides, miR-335 may serve as an oncogene or tumor suppressor via regulating different targets or pathways in tumor initiation, development, and metastasis. Furthermore, miR-335 also inuences tumor microenvironment and drug sensitivity. MiR-335 is regulated by various factors such as lncRNAs and microRNAs. In this review, we reveal the functions and targets of miR-335 in various cancers and its potential application as a possible biomarker in prognostic judgment and treatment of malignant tumors.