z-logo
open-access-imgOpen Access
Functions and Targets of miR-335 in Cancer
Author(s) -
Lingling Ye,
Fen Wang,
Hao Wu,
Hui Yang,
Yan Yang,
Yajun Ma,
Aili Xue,
Jing Zhu,
Meili Chen,
Jinyan Wang,
Quan An Zhang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s305098
Subject(s) - microrna , oncogene , biomarker , suppressor , cancer research , cancer , metastasis , biology , tumor initiation , bioinformatics , computational biology , medicine , gene , cell cycle , genetics
MicroRNAs (miRNAs) are small non-coding RNAs (18~25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in cancer. The expression level of miR-335 in tissues and cells varies with cancer types, and miR-335 has been proposed as a potential biomarker for the prognosis of cancer. Besides, miR-335 may serve as an oncogene or tumor suppressor via regulating different targets or pathways in tumor initiation, development, and metastasis. Furthermore, miR-335 also inuences tumor microenvironment and drug sensitivity. MiR-335 is regulated by various factors such as lncRNAs and microRNAs. In this review, we reveal the functions and targets of miR-335 in various cancers and its potential application as a possible biomarker in prognostic judgment and treatment of malignant tumors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here