Open AccessmiR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis
Author(s) -
Yaqian Niu,
Fang Liu,
Xiuyue Wang,
YuLing Chang,
Yanmei Song,
Chu Hui-yuan,
Shaowen Bao,
Che Chen
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s304117
Subject(s) - anaerobic glycolysis , glycolysis , glut1 , pi3k/akt/mtor pathway , protein kinase b , cancer research , pten , microrna , pkm2 , biology , chemistry , microbiology and biotechnology , glucose uptake , biochemistry , pyruvate kinase , signal transduction , metabolism , gene , endocrinology , insulin
The mortality and morbidity of hepatocellular carcinoma (HCC) are still unacceptably high, despite decades of extensive studies. Aerobic glycolysis is a hallmark of cancer metabolism, closely relating to invasion and metastasis of HCC. MicroRNAs (miRNAs) are involved in the regulation of aerobic glycolysis. miR-183-5p , an oncogenic miRNA, is highly expressed in HCC, but the regulatory mechanism of miR-183-5p in migration, invasion and aerobic glycolysis in HCC remains unclear.