Open AccessGDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death
Author(s) -
Zizhen Zhang,
Fangyu Ju,
Fei Chen,
Haoyue Wu,
Jingyu Chen,
Jing Zhong,
Linlin Shao,
Shu Zheng,
Liangjing Wang,
Min Xue
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s302334
Subject(s) - necroptosis , colorectal cancer , in vivo , medicine , cancer , pharmacology , programmed cell death , ripk1 , cancer research , apoptosis , biology , microbiology and biotechnology , biochemistry
Chemoresistance to 5-fluorouracil (5-Fu) is common in colorectal cancer (CRC). Programmed necrosis (necroptosis) is an alternative form of programmed cell death regulated by receptor-interacting protein kinase (RIPK) 1 and 3, assumed as a novel target of cancer therapy. In this study, we aimed to explore whether a novel small molecular agent GDC-0326 could facilitate the effect of 5-Fu through necroptosis.