Open AccessRPN2 Predicts Poor Prognosis and Promotes Bladder Cancer Growth and Metastasis via the PI3K-Akt Pathway
Author(s) -
Chenglin Han,
Shuxiao Chen,
Haizhen Ma,
Xiangchuan Wen,
Zilong Wang,
Yingkun Xu,
Xunbo Jin,
Xiao Yu,
Muwen Wang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s300480
Subject(s) - gene knockdown , cancer research , in vivo , metastasis , oncogene , pi3k/akt/mtor pathway , medicine , biology , cancer , signal transduction , microbiology and biotechnology , gene , cell cycle , biochemistry
Ribophorin II (RPN2) is a highly conserved glycoprotein involved in the N-linked glycosylation of multiple proteins. RPN2 was reported to be associated with malignant phenotype in several tumors. However, the function of RPN2 in bladder cancer (BCa) remains unclear.