Open AccessEffect of GLUT1 Inhibition and Autophagy Modulation on the Growth and Migration of Laryngeal Carcinoma Stem Cells Under Hypoxic and Low-Glucose Conditions
Author(s) -
Xiaohong Chen,
Jia Liu,
Jiang-Tao Zhong,
ShuiHong Zhou,
Jun Fan
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s300423
Subject(s) - autophagy , glucose transporter , glut1 , stem cell , cancer stem cell , chemistry , cancer research , microbiology and biotechnology , apoptosis , gene knockdown , gene silencing , abcg2 , biology , endocrinology , transporter , atp binding cassette transporter , biochemistry , gene , insulin
Enhanced glucose uptake and autophagy are means by which cells adapt to stressful microenvironments. In this study, we investigated the roles of glucose transporter-1 (GLUT-1) and autophagy in laryngeal carcinoma stem cells under hypoxic and low-glucose conditions.