Open AccessP4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization
Author(s) -
Qiyan Wang,
Junwen Zhang,
Sheng Fang,
Jialin Wang,
Xiangming Han,
Fusheng Liu,
Guishan Jin
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s299977
Subject(s) - microglia , glioma , gene knockdown , cancer research , cell culture , biology , pathology , immunology , medicine , inflammation , genetics
Polarization of microglia cells in the glioma microenvironment is closely related to the malignant progression and invasion of gliomas. Prolyl 4-hydroxylase subunit α1 (P4HA1) is the rate-limiting subunit of prolyl 4-hydroxylase (P4H). In previous studies, we showed that P4HA1 could promote the proliferation, migration, and invasion of glioma cells, but the specific mechanisms through which this occurs have not been fully elucidated.