Open Access3D Culture of Circulating Tumor Cells for Evaluating Early Recurrence and Metastasis in Patients with Hepatocellular Carcinoma
Author(s) -
Congli Hu,
Yanjun Zhang,
Xiaofeng Zhang,
Fei Xiang,
Zhang Hai,
Chunguang Li,
Bin Sun
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s298427
Subject(s) - circulating tumor cell , epithelial cell adhesion molecule , metastasis , cancer research , spheroid , hepatocellular carcinoma , medicine , in vivo , pathology , cell culture , cancer , biology , microbiology and biotechnology , genetics
Circulating tumor cells (CTCs) are considered to be a key factor involved in tumor metastasis. However, the isolation and culture of CTCs in vitro remains challenging, and their clinical application for predicting prognosis and survival is still limited. The development of accurate evaluating system for CTCs will benefit for clinical assessment of HCC.