Open AccessLong Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis
Author(s) -
Liping Mou,
Lili Wang,
Shaoming Zhang,
Qinghua Wang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s297969
Subject(s) - gene knockdown , carcinogenesis , radiosensitivity , microrna , biology , cancer research , microbiology and biotechnology , downregulation and upregulation , cell growth , long non coding rna , rna , chemistry , cell culture , gene , medicine , biochemistry , genetics , radiation therapy
Abnormal expression of long noncoding RNAs (lncRNAs) was often involved in tumorigenesis and radiosensitivity of various cancers. The aim of this study was to explore the biological function and regulatory mechanism of lncRNA long intergenic non-protein coding RNA 1410 (LINC01410) in tumorigenesis and radiosensitivity of neuroblastoma (NB).