Open AccessCD8+CD39+ T Cells Mediate Anti-Tumor Cytotoxicity in Bladder Cancer
Author(s) -
Wenjie Zhu,
Zihan Zhao,
Baofu Feng,
Wenhao Yu,
Ji Li,
Hongqian Guo,
Rong Yang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s297272
Subject(s) - bladder cancer , immunotherapy , cd8 , medicine , tumor infiltrating lymphocytes , flow cytometry , cancer research , immune system , cytotoxic t cell , stage (stratigraphy) , oncology , cancer , immunology , in vitro , biology , paleontology , biochemistry
Although immunotherapy works well in parts of patients with bladder cancer (BLCA), its overall response rate of anti-PD-1 inhibitors remains unsatisfactory. Besides, growing evidence shows that tumor-infiltrating lymphocytes (TILs) immunotherapy has demonstrated excellent efficacy in various cancers. Considering the huge heterogeneity and low overall survival rate of BLCA, it is urgent to explore the new immune checkpoints (ICs) or TILs therapy to improve the survival prognosis for BLCA patients.