Open AccessLong Noncoding RNA ZEB1-AS1 Downregulates miR-23a, Promotes Tumor Progression, and Predicts the Survival of Oral Squamous Cell Carcinoma Patients
Author(s) -
Xue Wang,
Yan Guo,
Chunyu Wang,
Qiang Wang,
Guangqi Yan
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s297209
Subject(s) - cancer research , cell growth , gene knockdown , long non coding rna , gene silencing , tumor progression , downregulation and upregulation , biology , cell , cell migration , competing endogenous rna , in vivo , cell culture , cancer , gene , biochemistry , genetics , microbiology and biotechnology
Long non-coding RNAs (lncRNAs) are implicated in cancer-related biological processes such as cell proliferation, cell cycle progression, cell migration, cell invasion, and chemoresistance. However, the effects of the lncRNA ZEB1-AS1 on oral squamous cell carcinoma (OSCC) have not been adequately demonstrated. The aims of our current study were to explore the roles of lncRNA ZEB1-AS1 in OSCC progression to reveal the potential mechanism.