Open AccessREG4 is a Potential Biomarker for Radiochemotherapy Sensitivity in Colorectal Cancer
Author(s) -
Lei Gao,
WU Xingjun,
Libo Zhang,
Yang Dai,
Zhe Zhu,
Yunqing Zhi,
Kaijing Wang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s296031
Subject(s) - colorectal cancer , biomarker , medicine , randomized controlled trial , oncology , tissue microarray , sensitivity (control systems) , bioinformatics , cancer , cancer research , biology , genetics , electronic engineering , engineering
Colorectal cancer (CRC) is one of the most common types of malignancies, and radiochemotherapy (RCT) followed by surgery is the recommended approach for CRC treatment. However, some cases do not respond to first-line conventional chemotherapy or even progress further after treatment. Moreover, there is a risk of severe side effects, such as radiodermatitis. Therefore, identifying predictors for RCT sensitivity is an essential step toward predicting and eventually overcoming resistance.