Open AccessET-1 Promotes Epithelial–Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells via the microRNA-489-3p /TWIST Axis
Author(s) -
Huey En Tzeng,
Chih Hsin Tang,
ChunHao Tsai,
ChihHui Chiu,
Min Wu,
Yun Yen
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s294312
Subject(s) - epithelial–mesenchymal transition , cancer research , vimentin , microrna , downregulation and upregulation , gene knockdown , cell migration , metastasis , wnt signaling pathway , head and neck squamous cell carcinoma , cell , cancer , biology , cell culture , medicine , pathology , signal transduction , head and neck cancer , microbiology and biotechnology , immunohistochemistry , gene , biochemistry , genetics
Oral squamous cell carcinoma (OSCC) constitutes almost 90% of head and neck malignancies and has a poor prognosis. To improve the efficacy of OSCC therapy, it is of great significance to explore other therapy for OSCC. Endothelin-1 (ET-1), a potent vasoconstrictor peptide, is implicated in cancer pathogenesis. Moreover, ET-1 promotes epithelial-mesenchymal transition (EMT) during the development of human cancers. We further to found that ET-1 exposure induced EMT in human squamous cell carcinoma cell lines SCC4 and SAS, by enhancing the expression of EMT biomarkers N-cadherin and vimentin and reducing E-cadherin expression via upregulation of the transcription factor TWIST.