Open AccessCalycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-κB Pathway
Author(s) -
Yu Zhang,
Jianqiang Zhang,
Tong Zhang,
Hui Xue,
WenBo Zuo,
Yannan Li,
Yue Zhao,
Geng Sun,
Zhong-Ren Fu,
Qing Zhang,
Xue Zhao,
Yue Teng,
Anqi Wang,
Jiazhu Li,
Ying Wang,
ChengHao Jin
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s292388
Subject(s) - propidium iodide , apoptosis , microbiology and biotechnology , calycosin , chemistry , cancer cell , cell cycle , cancer research , biology , programmed cell death , biochemistry , cancer , formononetin , daidzein , genetics , genistein , endocrinology
Calycosin, an active compound in plants, can promote the apoptosis of various cancer cells; however, the mechanism by which it regulates reactive oxygen species (ROS) in gastric cancer (GC) cells remains unclear.