Open AccessILT4 in Colorectal Cancer Cells Induces Suppressive T Cell Contexture and Disease Progression
Author(s) -
Zijiang Yang,
Aiqin Gao,
Wenjing Shi,
Jingnan Wang,
Xianchao Zhang,
Zhengyan Xu,
Tingting Xu,
Yan Zheng,
Yuping Sun,
Fei Yang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s290348
Subject(s) - tumor microenvironment , cd8 , foxp3 , cancer research , t cell , flow cytometry , immune checkpoint , colorectal cancer , immunohistochemistry , immune system , pd l1 , cytotoxic t cell , metastasis , cell , cancer , medicine , biology , immunotherapy , pathology , immunology , biochemistry , genetics , in vitro
Immune checkpoint blockade (ICB) therapy shows little or no clinical benefit in most colorectal cancer (CRC) patients, due to the immunosuppressive T cell contexture in the tumor microenvironment (TME). Immunoglobulin-like transcript (ILT) 4 is an immunosuppressive molecule in myeloid cells. ILT4 is enriched in solid tumor cells, facilitating their proliferation, invasion, and metastasis. However, the regulatory role of ILT4 in T cell immunity of CRC is still undetermined. Here, we aimed to explore how tumor cell-derived ILT4 orchestrates T cell infiltration, subset distribution, and function in CRC.