Open AccessTargeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma
Author(s) -
Qiaoping Zheng,
Guifang Gan,
Xianfu Gao,
Qiang Luo,
Fuxiang Chen
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s288692
Subject(s) - apoptosis , gene knockdown , cancer research , flow cytometry , cell growth , cell culture , in vivo , cell , biology , small hairpin rna , viability assay , microbiology and biotechnology , biochemistry , genetics
Indolamine 2,3-dioxygenase (IDO) is the rate limiting enzyme of tryptophan degradation and is a negative prognostic factor in oral squamous cell carcinoma (OSCC) patients, while the underlying molecular mechanism remains unclear. This research aimed to explore the IDO expression and its biological functions in OSCC.