Open AccessImmunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer
Author(s) -
Xueqing Huang,
Guanyu Ruan,
Guifen Liu,
Yuqin Gao,
Pengming Sun
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s288332
Subject(s) - immunohistochemistry , ovarian cancer , coactivator , receptor , medicine , cancer , estrogen related receptor alpha , clinical significance , cancer research , lymph node , estrogen receptor , oncology , endocrinology , breast cancer , biology , gene , transcription factor , biochemistry
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and estrogen-related receptor alpha (ERRα) play a vital role in various human cancers. The purpose of this study was to investigate whether the PGC-1α/ERRα axis could serve as an effective prognostic marker in ovarian cancer (OC).