Open AccessLobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway
Author(s) -
Jia-hui Rong,
Dong Dong Li,
Yuliang Li
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s288012
Subject(s) - pi3k/akt/mtor pathway , apoptosis , tunel assay , protein kinase b , cancer research , flow cytometry , cell growth , viability assay , a549 cell , medicine , cell cycle , chemistry , pharmacology , immunology , biochemistry
In recent years, radioactive 125 I seed implantation combined with chemotherapy has been regarded as a safe and effective treatment for advanced non-small cell lung cancer (NSCLC). However, the mechanism underlying this success is still unclear.