Open AccessPreliminary Study on the Identification of BRAFV600E Mutation in Colorectal Cancer by Near-Infrared Spectroscopy
Author(s) -
Jiale Duan,
Yanping Yang,
Lei Yin,
Xue Zhang,
Yi Tang,
Shuxian Zhang,
Hanjuan Gong,
Ming Xiao,
Ming Li,
Qingshu Li,
Xian Li,
Lian Yang,
Fan Qiu,
Yalan Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s287814
Subject(s) - colorectal cancer , immunohistochemistry , mutant , medicine , mutation , biomarker , cancer , gold standard (test) , v600e , wild type , cancer research , gene , pathology , biology , genetics
In metastatic colorectal cancer (mCRC), the B-type Raf kinase (BRAF) V600E mutation is a molecular biomarker of poor prognosis and is of great importance to drug target. Currently, the commonly used methods for detecting BRAF V600E mutation include immunohistochemistry (IHC) and gene sequencing, but both present certain limitations. Near-infrared (NIR) spectroscopy is a spectroscopy technology that takes advantage of the electromagnetic wavelength between visible light and mid-infrared light.