Open AccessOverexpression of LncRNA SNHG1 Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma
Author(s) -
Xin Wang,
Yang Song,
Xuechao Lv,
Lina Wang,
Chunmei Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s285536
Subject(s) - oncolytic virus , cancer research , gene knockdown , oncolytic adenovirus , medicine , biomarker , chemotherapy , cell , in vivo , cancer , cell growth , oncology , cell culture , biology , tumor cells , biochemistry , microbiology and biotechnology , genetics
As the most prevalent type of head and neck cancer, oral squamous-cell carcinoma (OSCC) accounts for nearly 90% of all oral cancer cases. Despite great progress having been made in the diagnosis and treatment of OSCC recently, the survival rate of OSCC patients has not risen remarkably. Chemotherapy is commonly used for OSCC treatment; however, the emergence of chemoresistance limits its long-term curative effect. Therefore, identifying effective biomarkers and molecular mechanisms is essential to the development of therapeutic strategies for OSCC.