Open AccessKnockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway
Author(s) -
Min Guo,
Shuo Li,
Zhao Xi,
Ying Yuan,
Bin Zhang,
Yifu Guan
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s285153
Subject(s) - gene knockdown , cyclin dependent kinase 6 , microrna , cell growth , cell cycle , paclitaxel , cancer research , biology , clone (java method) , cell , cell culture , chemistry , microbiology and biotechnology , cancer , gene , cyclin dependent kinase 2 , biochemistry , genetics
Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on the non-coding RNA network of the paclitaxel-resistant ovarian cancer cell A2780/PTX.