Open AccessSinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1
Author(s) -
Xun Qu,
Bing Yu,
Mengmei Zhu,
Xiaomei Li,
Lishan Ma,
Chuyin Liu,
Yixing Zhang,
Zhongping Cheng
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s284261
Subject(s) - sinomenine , ovarian cancer , biology , cancer research , transcriptome , mitosis , cell cycle , cancer , cancer cell , gene , ovarian tumor , kegg , microbiology and biotechnology , gene expression , genetics , pharmacology
Ovarian cancer is one of the most common gynecological cancers worldwide. While, therapies against ovarian cancer have not been completely effective, sinomenine has been proved to have anti-tumor activity in various cancer cells. However, study of its anti-ovarian cancer effect is still rare, and the underlying mechanism has not been elucidated. Therefore, we aim to explore the mechanism of sinomenine anti-ovarian cancer.