Open Access<p>Hypoxic Tumor-Derived Exosomal Circ0048117 Facilitates M2 Macrophage Polarization Acting as miR-140 Sponge in Esophageal Squamous Cell Carcinoma</p>
Author(s) -
Qijue Lu,
Xinyu Wang,
Ji Zhu,
Xiang Fei,
Hezhong Chen,
Chunguang Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s284192
Subject(s) - microvesicles , exosome , macrophage polarization , cancer research , tumor microenvironment , microrna , flow cytometry , chemistry , western blot , tumor progression , m2 macrophage , downregulation and upregulation , microbiology and biotechnology , medicine , biology , macrophage , cancer , tumor cells , in vitro , biochemistry , gene
Hypoxia and tumor-associated macrophage (TAM) are key regulators in remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC). Hypoxia could stimulate tumor cells to secrete more exosomes and activate TAMs to M2 type. Here, we investigated the function and the underlying mechanism of tumor-derived exosomal hsa-circ-0048117 in TAM polarization in ESCC. Collectively, these data indicate that PC cells generate miR-301a-3p-rich exosomes in a hypoxic microenvironment, which then polarize macrophages to promote malignant behaviors of PC cells.