Open Access<p>A Circular RNA Derived from Golgi Glycoprotein 1 mRNA Regulates <em>KRAS</em> Expression and Promotes Colorectal Cancer Progression by Targeting microRNA-622</p>
Author(s) -
Shuhong Hao,
Rongfeng Qu,
Chunmei Hu,
Min Wang,
Yarong Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s284032
Subject(s) - kras , microrna , messenger rna , microbiology and biotechnology , chemistry , transfection , cancer research , viability assay , colorectal cancer , circular rna , cell growth , biology , cell , cancer , gene , biochemistry , genetics
Circular RNAs (circRNAs) represent a distinct class of non-coding RNAs that have attracted substantial research attention in recent years. We identified a novel circRNA derived from golgi glycoprotein 1 mRNA (circ_GLG1), the role of which is unknown in colorectal cancer (CRC). The purpose of this study was to explore the potential roles and mechanisms of circ_GLG1 in CRC.