Open Access<p>Exosomal Transfer of Macrophage-Derived miR-223 Confers Doxorubicin Resistance in Gastric Cancer</p>
Author(s) -
Huijie Gao,
Jincheng Ma,
Yanhui Cheng,
Peiming Zheng
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s283542
Subject(s) - microvesicles , doxorubicin , flow cytometry , exosome , macrophage , cancer research , microrna , transfection , gene knockdown , microbiology and biotechnology , cell culture , chemistry , biology , apoptosis , medicine , in vitro , chemotherapy , biochemistry , genetics , gene
Macrophages are a major component of the tumour microenvironment and play an important role in chemoresistance of cancer. However, how exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of doxorubicin resistance in gastric cancer (GC) are not clearly defined. The aim of this study was to investigate whether macrophage-derived exosomes mediate doxorubicin resistance in GC.