Open AccessExosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p/TNFRSF1B Pathway
Author(s) -
Yandong Zhou,
Yi Zhu,
Xin Dong,
Guodong Cao,
Yongzhou Li,
Yiqun Fan,
Qing Chen,
Haolei Cai,
Yulian Wu
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s282319
Subject(s) - osteoclast , microvesicles , pancreatic cancer , microrna , cancer research , medicine , luciferase , endocrinology , microbiology and biotechnology , chemistry , cancer , biology , cell culture , transfection , biochemistry , receptor , genetics , gene
Pancreatic cancer (PC) was regarded as the 4th principal cause of cancer-related fatalities in the United States and patients usually suffered from severe nutrition deficiency, muscle wasting, as well as bone loss. In our previous research, we have found that PC-derived exosomes potentially initiate insulin resistance in skeletal muscle cells. However, the role of exosomes in the PC-related bone loss remains unknown.