Open Access<p>LncRNA CASC15 is Upregulated in Osteosarcoma Plasma Exosomes and CASC15 Knockdown Inhibits Osteosarcoma Progression by Regulating miR-338-3p/RAB14 Axis</p>
Author(s) -
Hongliang Zhang,
Jun Jun Wang,
Tingting Ren,
Yi Huang,
Yan Yu,
Chenglong Chen,
Qingshan Huang,
Wei Guo
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s282053
Subject(s) - gene knockdown , microvesicles , downregulation and upregulation , cancer research , microrna , western blot , osteosarcoma , cell growth , tumor progression , microarray analysis techniques , metastasis , chemistry , biology , cell culture , cancer , gene expression , gene , biochemistry , genetics
Currently, plenty of studies have demonstrated that lncRNAs can act as crucial roles during the progression of various tumors, including osteosarcoma (OS), and emerging evidences indicated that lncRNAs are abundant and stable in exosomes. The objective of this study is to reveal the dysregulated lncRNAs in OS plasma exosomes and explore their functions in OS.