Open AccessSmall Proline-Rich Protein 2B Facilitates Gastric Adenocarcinoma Proliferation via MDM2-p53/p21 Signaling Pathway
Author(s) -
Ling Yao,
Jun Yan,
Fei Cheng,
Lihong Gan,
Yaqin Huang,
Li Zheng,
Nian Fang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s281032
Subject(s) - cancer research , gene silencing , gene knockdown , cell cycle , apoptosis , immunohistochemistry , mdm2 , signal transduction , cyclin dependent kinase 1 , flow cytometry , biology , medicine , pathology , microbiology and biotechnology , gene , biochemistry
The small proline-rich protein 2B (SPRR2B) was firstly reported as a member of the cross-linked envelope protein in keratinocytes. The effect of SPRR2B in gastric adenocarcinoma (GC) remains unclear. This study initially explored the clinical significance of SPRR2B in GC patients as well as its role in tumor progression.