Open Access<p>Upregulated <em>circPDK1</em> Promotes RCC Cell Migration and Invasion by Regulating the <em>miR-377-3P-NOTCH1</em> Axis in Renal Cell Carcinoma</p>
Author(s) -
Zhenlin Huang,
Yinghui Ding,
Lu Zhang,
Siyuan He,
Zhang Jia,
Chaohui Gu,
Tao Wang,
Hao Li,
Xiang Li,
Zhibo Jin,
Yanqiao Ding,
Jinjian Yang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s280434
Subject(s) - gene knockdown , metastasis , cancer research , biology , ectopic expression , in vivo , competing endogenous rna , renal cell carcinoma , downregulation and upregulation , cell growth , cancer , cell , cell migration , microrna , long non coding rna , cell culture , medicine , pathology , gene , genetics
Circular RNAs (circRNAs) are novel clusters of endogenous noncoding RNAs (ncRNAs) that are involved in the regulation of multiple biological processes in diverse types of cancers. However, the roles and precise mechanisms of circRNAs in renal cell carcinoma (RCC) occurrence and progression have not been clearly elucidated.