Open AccessProgesterone Receptor Together with PKCα Expression as Prognostic Factors for Astrocytomas Malignancy
Author(s) -
Denisse Arcos-Montoya,
Talía Wegman-Ostrosky,
Sonia Iliana Mejía-Pérez,
Marisol de la FuenteGranada,
Ignacio CamachoArroyo,
Alejandro GarcíaCarrancá,
Marco A. Velasco-Velázquez,
Joaquı́n Manjarrez-Marmolejo,
Aliesha GonzálezArenas
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s280314
Subject(s) - malignancy , astrocytoma , colocalization , phosphorylation , protein kinase c , cancer research , medicine , glioma , biology , pathology , microbiology and biotechnology
Astrocytomas are the most common and aggressive primary brain tumors, and they are classified according to the degree of malignancy on a scale of I to IV, in which grade I is the least malignant and grade IV the highest. Many factors are related to astrocytomas progression as progesterone receptor (PR), whose transcriptional activity could be regulated by phosphorylation by protein kinase C alpha (PKCα) at the residue Ser400. Our aim was to investigate if PR phosphorylation together with PKCα expression could be used as a prognostic factor for astrocytomas malignancy.