Open AccessIdentification of Critical Pathways and Potential Key Genes in Poorly Differentiated Pancreatic Adenocarcinoma
Author(s) -
Yuanxiang Lu,
Dongxiao Li,
Ge Liu,
Erwei Xiao,
Senmao Mu,
Yamin Pan,
Fangyuan Qin,
Yaping Zhai,
Shaofeng Duan,
Deyu Li,
Guohua Yan
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s279287
Subject(s) - gene , carcinogenesis , cancer research , phenotype , gene expression , biology , rna seq , gene expression profiling , pancreatic cancer , signal transduction , computational biology , adenocarcinoma , transcriptome , cancer , genetics
The poorly differentiated pancreatic adenocarcinoma (PDAC) is an extremely lethal neoplasm without effective biomarkers for early detection and prognosis prediction, which is characteristically unresponsive to chemotherapeutic regimens. This study aims at searching for key genes which could be applied as novel prognostic biomarkers and therapeutic targets in PDAC.