Open AccessThe Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development
Author(s) -
Danielle Benedict Sacdalan,
Josephine Anne Lucero
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s278089
Subject(s) - immunosuppression , inflammation , immune system , tumor microenvironment , context (archaeology) , medicine , biomarker , immunology , cancer , immune checkpoint , immunotherapy , nivolumab , biology , paleontology , biochemistry
Evasion of immune destruction is considered one of the hallmarks of cancer. Chronic inflammation can enable immune escape by suppressing immune surveillance and permitting the development of tumors and creating a tumor microenvironment that sustains cancer. This includes generating mechanisms that prevent the effectiveness of anti-tumor treatment including immune checkpoint inhibitor therapy. In this review, we explore the interplay of inflammation and immunosuppression, their effects on the tumor microenvironment, and their implications for immune checkpoint inhibitor therapy particularly in the context of predictive biomarkers for their use.