Open Access<p>Low Levels of SPARC are Associated with Tumor Progression and Poor Prognosis in Human Endometrial Carcinoma</p>
Author(s) -
Ling Wang,
Wei Wang,
Yangchun Xu,
Qiang Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s277795
Subject(s) - osteonectin , gene knockdown , matricellular protein , cancer research , immunohistochemistry , cell growth , in vivo , metastasis , apoptosis , cell culture , biology , medicine , pathology , cancer , microbiology and biotechnology , extracellular matrix , biochemistry , alkaline phosphatase , genetics , osteocalcin , enzyme
SPARC (secreted protein acidic and rich in cysteine), also known as osteonectin, BM-40, and 43 K protein, is a matricellular protein associated with various tumor progressions. The aim of this research was to investigate the prognostic value of SPARC in endometrial carcinoma (EC) and its function in cancer cell invasion and metastasis.