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The prognosis of gastric cancer (GC) is poor with a median overall survival (OS) of less than 12 months in advanced-stage disease. The search for distinct genetic subgroups of GC patients and predictive biomarkers is ongoing. While BRCA1 or BRCA2 germline mutations (gBRCAm) have potential therapeutic implications in ovarian, breast and pancreatic cancers, their significance in GC patients has not been established.

oncotargets and therapy

&lt;p&gt;Clinical Characteristics and Prognosis of Gastric Cancer Patients with &lt;em&gt;BRCA 1/2&lt;/em&gt; Germline Mutations: Report of Ten Cases and a Literature Review&lt;/p&gt;