Open Access<p>Raltitrexed Enhances the Antitumor Effect of Apatinib in Human Esophageal Squamous Carcinoma Cells via Akt and Erk Pathways</p>
Author(s) -
Hongchao Zhen,
Guangxin Li,
Pengfei Zhao,
Ying Zhang,
Jing Wang,
Yu Jin,
Bangwei Cao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s276125
Subject(s) - apatinib , raltitrexed , cancer research , protein kinase b , apoptosis , cell growth , western blot , medicine , chemistry , cancer , biochemistry , colorectal cancer , oxaliplatin , gene
Apatinib has been proved effective in the treatment of advanced gastric cancer and a variety of solid tumors. Raltitrexed is emerging as a promising alternative for treating advanced colorectal cancer in China. This work aims to study the combinatory antitumor effect of apatinib and raltitrexed on human esophageal squamous carcinoma cells (ESCC).