Open Access<p>Secretory Pathway Kinase <em>FAM20C</em>, a Marker for Glioma Invasion and Malignancy, Predicts Poor Prognosis of Glioma</p>
Author(s) -
Shaonan Du,
Sheng Guan,
Chen Zhu,
Qing Guo,
Ji Cao,
Gefei Guan,
Wen Cheng,
Cheng Peng,
Anhua Wu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s275452
Subject(s) - glioma , cancer research , malignancy , kegg , biology , gene , medicine , gene expression , genetics , transcriptome
Glioblastoma (GBM) is the most lethal primary cancer in adult central nervous system, and new strategies are desperately needed. The secretory pathway kinase or kinase-like proteins (SPKKPs) have been shown to mediate multiple physiological functions by phosphorylating extracellular proteins and proteoglycans. However, their roles in cancers, especially GBM, remain poorly defined.