Open Access<p>Genetic Variability in the microRNA Binding Sites of <em>BMPR1B</em>, <em>TGFBR1</em>, <em>IQGAP1</em>, <em>KRAS</em>, <em>SETD8</em> and <em>RYR3</em> and Risk of Breast Cancer in Colombian Women</p>
Author(s) -
Karen Mesa,
Justo Lorenzo Bermejo,
Diana Torres,
Michael Gilbert,
Christoph Plass,
Ute Hamann
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s274431
Subject(s) - kras , microrna , biology , breast cancer , genetics , genetic variation , oncology , gene , medicine , cancer , mutation
Genetic variants in microRNA (miR) binding sites affect the regulation of miR-dependent gene expression and have been linked to the risk of a variety of cancers including breast cancer (BC). Most BC risk variants had been identified in women of European and Asian ancestry, but genetic data for Hispanic women are scarce. Here, we investigate the association between six variants in miR binding sites and BC risk in Colombian women.