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Post hoc analysis of the LUX-Lung 3 and 6 (LL3/6) Phase III trials showed that tolerability-guided dose-adjustments of afatinib reduced treatment-related adverse events (TRAEs) without affecting progression-free survival (PFS) in patients with epidermal growth factor receptor ( EGFR ) mutation-positive non-small-cell lung cancer (NSCLC). The current post hoc analysis evaluated outcomes of tolerability-guided dose adjustments of afatinib in patients enrolled in the LL3/6/7 trials in Chinese centers.

oncotargets and therapy

&lt;p&gt;Effect of Dose Adjustments on the Safety and Efficacy of Afatinib in Chinese Patients with &lt;em&gt;EGFR&lt;/em&gt;-Mutated Non-Small Cell Lung Cancer Who Participated in the LUX-Lung Clinical Trial Program&lt;/p&gt;