Open Access<p>Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy</p>
Author(s) -
Xiaoqing Hu,
Jiabin Wang,
Jiannan Chai,
Xiaoli Yu,
Yunhan Zhang,
YuQi Feng,
Jianchun Qin,
Huimei Yu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s273435
Subject(s) - mitophagy , apoptosis , endoplasmic reticulum , viability assay , mitochondrion , cisplatin , parkin , microbiology and biotechnology , pink1 , mtt assay , reactive oxygen species , unfolded protein response , chemistry , biology , cancer research , pharmacology , autophagy , biochemistry , medicine , pathology , chemotherapy , genetics , disease , parkinson's disease
The chemoresistance and toxicity of traditional chemotherapeutic drugs have become obstacles to their antitumor effects in ovarian cancers. Therefore, it is particularly important to develop new anticancer drugs to increase target sensitivity and reduce the toxicity of chemotherapy drugs. As key organelles, the endoplasmic reticulum and mitochondria play important role in chemoresistance. Cells become resistant to drugs by maintaining the homeostasis of the endoplasmic reticulum and mitochondria. Chaetomugilin J, a metabolite isolated from Polygonatum sibiricum , belongs to the Chaetomium family and exhibits potent cytotoxicity. In this study, we aimed to explore the mechanistic link between apoptosis and endoplasmic reticulum stress, mitophagy and mitochondrial dysfunction induced by chaetomugilin J combined with cisplatin in the ovarian cancer cell line A2780.