Open AccessThe Significance of HOXC11 and LSH in Survival Prediction in Gastric Adenocarcinoma
Author(s) -
Xin Peng,
Jingyue Sun,
Yao Long,
Desheng Xiao,
Jianhua Zhou,
Yongguang Tao,
Shuang Liu
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s273195
Subject(s) - stage (stratigraphy) , immunohistochemistry , malignancy , cancer , gastric adenocarcinoma , adenocarcinoma , clinical significance , pathological , medicine , apoptosis , pathology , oncology , cancer research , gastroenterology , biology , paleontology , biochemistry
Gastric adenocarcinoma is one of the most important causes of cancer death and lacks effective treatment. Eighty-four gastric adenocarcinoma tissue samples along with the clinical information were collected. After analyzing the expression of HOXC11 and LSH in the gastric adenocarcinoma tissues, we explored the prognosis of patients and its correlation with clinical characteristics. Both HOXC11 and LSH were over-expressed in MKN-45 cell lines to verify the effect of high expression of HOXC11 and LSH on GAC.