Open Access<p>Identification and Validation of <em>STAT6</em> as a Prognostic and Predictive Biomarker in Acute Myeloid Leukemia</p>
Author(s) -
Wei Liu,
Feiyue Zhu,
Jiazhuo Yan,
Yi Liu,
Cong Chen,
Kaixuan Zhang,
Xielan Zhao,
Jingyuan Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s272757
Subject(s) - medicine , myeloid leukemia , biomarker , identification (biology) , myeloid , cancer research , oncology , biology , genetics , botany
Acute myeloid leukemia (AML) is one of the most common hematological diseases in adults. The overall survival rate remains unsatisfactory. It is urgent to identify potential prognostic biomarkers and develop new molecular therapeutic strategies for AML. Signal transducer and activator of transcription (STAT) is a family of genes that encode intracellular transcription factors. STATs are associated with leukemogenesis, cellular transformation, and cell cycle in AML.