Open Access<p>Integrated RNA Sequencing and Single-Cell Mass Cytometry Reveal a Novel Role of LncRNA HOXA-AS2 in Tumorigenesis and Stemness of Hepatocellular Carcinoma</p>
Author(s) -
Qinchen Lu,
Jiamin Gao,
Shaomei Tang,
Li Z,
Xi Wang,
Caiwang Deng,
Jiaxin Hu,
Yuting Tao,
Qiuyan Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s272717
Subject(s) - hepatocellular carcinoma , carcinogenesis , cancer research , mass cytometry , flow cytometry , long non coding rna , cell , biology , rna , microbiology and biotechnology , chemistry , genetics , gene , phenotype
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play critical roles in the development of many cancer types. However, the changes of lncRNAs expression profiles in hepatocarcinogenesis remain largely unknown. Therefore, the purpose of this study was to identify the clinical significance, oncogenic functions, and potential mechanism of cancer-related lncRNAs in hepatocellular carcinoma (HCC).