Open Access<p>CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway</p>
Author(s) -
Rui Cheng,
Wang Bi,
Xinran Cai,
Zhi-shan Chen,
Qiang Du,
Linlin Zhou,
Jing-min Ye,
Yanling Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s271891
Subject(s) - vasculogenic mimicry , vimentin , cancer research , mmp2 , small hairpin rna , pi3k/akt/mtor pathway , protein kinase b , cyclin d1 , gene knockdown , chemistry , angiogenesis , microbiology and biotechnology , cell culture , biology , cell , signal transduction , cell cycle , medicine , pathology , downregulation and upregulation , immunohistochemistry , cancer , metastasis , genetics , biochemistry , gene
CD276 protein expression and vasculogenic mimicry (VM) formation are associated with the poor prognosis of hepatocellular carcinoma (HCC) patients. Although both the effects of CD276 and VM formation involve the activation of matrix metalloproteinases, and their relationship has not yet been explored. The following study investigated the effect of CD276 expression on VM formation and the potential mechanisms.